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Journal of Biomedical Optics

Alveolar bone dynamics in osteoporotic rats treated with raloxifene or alendronate: confocal microscopy analysis
Author(s): Gabriel Ramalho-Ferreira; Leonardo Perez Faverani; Gustavo Augusto Grossi-Oliveira; Tetuo Okamoto; Roberta Okamoto
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Paper Abstract

In this study, the characteristics of the alveolar bone of rats with induced osteoporosis were examined. Thirty-two rats were divided into four groups according to the induction of osteoporosis and drugs administered: OG, osteoporotic rats without treatment (negative control); SG, rats which underwent sham surgery ovariectomy (SHAM); alendronate (AG), osteoporotic rats treated with alendronate; and RG, osteoporotic rats treated with raloxifene (RG). On the 8th day after ovariectomy and SHAM surgeries, drug therapy was started with AG or RG. On the 52nd day, 20  mg/kg calcein was administered to all of the rats, and on the 80th day, 20  mg/kg alizarin red was administered. Euthanasia was performed on the 98th day. The bone area marked by fluorochromes was calculated and data were subjected to two-way ANOVA test and Tukey’s post-hoc test (p<0.05). The comparison of the induced osteoporosis groups showed no statistically significant differences in bone turnover only between RG and SG (p=0.074) and AG and OG (p=0.138). All other comparisons showed significant differences (p<0.001). The largest bone turnover was observed in RG and SG groups. RG was the medication that improved the dynamics of the alveolar bone of rats with induced osteoporosis, resembling that of healthy rats.

Paper Details

Date Published: 26 March 2015
PDF: 7 pages
J. Biomed. Opt. 20(3) 038003 doi: 10.1117/1.JBO.20.3.038003
Published in: Journal of Biomedical Optics Volume 20, Issue 3
Show Author Affiliations
Gabriel Ramalho-Ferreira, Univ. Estadual Paulista "Júlio de Mesquita Filho" (Brazil)
Leonardo Perez Faverani, Univ. Estadual Paulista "Júlio de Mesquita Filho" (Brazil)
Gustavo Augusto Grossi-Oliveira, Univ. Estadual Paulista "Júlio de Mesquita Filho" (Brazil)
Tetuo Okamoto, Univ. Estadual Paulista "Júlio de Mesquita Filho" (Brazil)
Roberta Okamoto, Univ. Estadual Paulista "Júlio de Mesquita Filho" (Brazil)


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