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Journal of Biomedical Optics • Open Access

Cerebral autoregulation in the preterm newborn using near-infrared spectroscopy: a comparison of time-domain and frequency-domain analyses
Author(s): Vibeke R. Eriksen; Gitte H. Hahn; Gorm Greisen

Paper Abstract

The aim was to compare two conventional methods used to describe cerebral autoregulation (CA): frequency-domain analysis and time-domain analysis. We measured cerebral oxygenation (as a surrogate for cerebral blood flow) and mean arterial blood pressure (MAP) in 60 preterm infants. In the frequency domain, outcome variables were coherence and gain, whereas the cerebral oximetry index (COx) and the regression coefficient were the outcome variables in the time domain. Correlation between coherence and COx was poor. The disagreement between the two methods was due to the MAP and cerebral oxygenation signals being in counterphase in three cases. High gain and high coherence may arise spuriously when cerebral oxygenation decreases as MAP increases; hence, time-domain analysis appears to be a more robust—and simpler—method to describe CA.

Paper Details

Date Published: 25 March 2015
PDF: 6 pages
J. Biomed. Opt. 20(3) 037009 doi: 10.1117/1.JBO.20.3.037009
Published in: Journal of Biomedical Optics Volume 20, Issue 3
Show Author Affiliations
Vibeke R. Eriksen, Copenhagen Univ. Hospital Rigshopitalet (Denmark)
Univ. of Copenhagen (Denmark)
Gitte H. Hahn, Copenhagen Univ. Hospital Rigshopitalet (Denmark)
Gorm Greisen, Copenhagen Univ. Hospital Rigshopitalet (Denmark)


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