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Journal of Biomedical Optics

Quantifying the correlation between photoplethysmography and laser Doppler flowmetry microvascular low-frequency oscillations
Author(s): Irina Mizeva; Costanzo Di Maria; Peter Frick; Sergey Podtaev; John Allen
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Paper Abstract

Photoplethysmography (PPG) and laser Doppler flowmetry (LDF) are two recognized optical techniques that can track low-frequency perfusion changes in microcirculation. The aim of this study was to determine, in healthy subjects, the correlation between the techniques for specific low-frequency bands previously defined for microcirculation. Twelve healthy male subjects (age range 18 to 50 years) were studied, with PPG and LDF signals recorded for 20 min from their right and left index (PPG) and middle (LDF) fingers. Wavelet analysis comprised dividing the low-frequency integral wavelet spectrum (IWS) into five established physiological bands relating to cardiac, respiratory, myogenic, neurogenic, and endothelial activities. The correlation between PPG and LDF was quantified using wavelet correlation analysis and Spearman correlation analysis of the median IWS amplitude. The median wavelet correlation between signals (right-left side average) was 0.45 (cardiac), 0.49 (respiratory), 0.86 (myogenic), 0.91 (neurogenic), and 0.91 (endothelial). The correlation of IWS amplitude values (right-left side average) was statistically significant for the cardiac (ρ=0.64, p<0.05) and endothelial (ρ=0.62, p<0.05) bands. This pilot study has shown good correlation between PPG and LDF for specific physiological frequency bands. In particular, the results suggest that PPG has the potential to be a low-cost replacement for LDF for endothelial activity assessments.

Paper Details

Date Published: 12 March 2015
PDF: 7 pages
J. Biomed. Opt. 20(3) 037007 doi: 10.1117/1.JBO.20.3.037007
Published in: Journal of Biomedical Optics Volume 20, Issue 3
Show Author Affiliations
Irina Mizeva, Institute of Continuous Media Mechanics (Russia)
Costanzo Di Maria, Freeman Hospital (United Kingdom)
Newcastle Univ. (United Kingdom)
Peter Frick, Institute of Continuous Media Mechanics (Russia)
Sergey Podtaev, Institute of Continuous Media Mechanics (Russia)
John Allen, Freeman Hospital (United Kingdom)
Newcastle Univ. (United Kingdom)

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