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Journal of Biomedical Optics

Drop coating deposition Raman spectroscopy of blood plasma for the detection of colorectal cancer
Author(s): Pengpeng Li; Changshui Chen; Xiaoyuan Deng; Hua Mao; Shaoqin Jin
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Paper Abstract

We have recently applied the technique of drop coating deposition Raman (DCDR) spectroscopy for colorectal cancer (CRC) detection using blood plasma. The aim of this study was to develop a more convenient and stable method based on blood plasma for noninvasive CRC detection. Significant differences are observed in DCDR spectra between healthy (n=105) and cancer (n=75) plasma from 15 CRC patients and 21 volunteers, particularly in the spectra that are related to proteins, nucleic acids, and β-carotene. The multivariate analysis principal components analysis and the linear discriminate analysis, together with leave-one-out, cross validation were used on DCDR spectra and yielded a sensitivity of 100% (75/75) and specificity of 98.1% (103/105) for detection of CRC. This study demonstrates that DCDR spectroscopy of blood plasma associated with multivariate statistical algorithms has the potential for the noninvasive detection of CRC.

Paper Details

Date Published: 10 March 2015
PDF: 5 pages
J. Biomed. Opt. 20(3) 037004 doi: 10.1117/1.JBO.20.3.037004
Published in: Journal of Biomedical Optics Volume 20, Issue 3
Show Author Affiliations
Pengpeng Li, South China Normal Univ. (China)
Changshui Chen, South China Normal Univ. (China)
Xiaoyuan Deng, South China Normal Univ. (China)
Hua Mao, Southern Medical Univ. (China)
Shaoqin Jin, Southern Medical Univ. (China)


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