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Journal of Biomedical Optics

Detection of canine skin and subcutaneous tumors by visible and near-infrared diffuse reflectance spectroscopy
Author(s): Blaž Cugmas; Tanja Plavec; Maksimilijan Bregar; Peter Naglič; Franjo Pernuš; Boštjan Likar; Miran Bürmen
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Paper Abstract

Cancer is the main cause of canine morbidity and mortality. The existing evaluation of tumors requires an experienced veterinarian and usually includes invasive procedures (e.g., fine-needle aspiration) that can be unpleasant for the dog and the owner. We investigate visible and near-infrared diffuse reflectance spectroscopy (DRS) as a noninvasive optical technique for evaluation and detection of canine skin and subcutaneous tumors ex vivo and in vivo. The optical properties of tumors and skin were calculated in a spectrally constrained manner, using a lookup table-based inverse model. The obtained optical properties were analyzed and compared among different tumor groups. The calculated parameters of the absorption and reduced scattering coefficients were subsequently used for detection of malignant skin and subcutaneous tumors. The detection sensitivity and specificity of malignant tumors ex vivo were 90.0% and 73.5%, respectively, while corresponding detection sensitivity and specificity of malignant tumors in vivo were 88.4% and 54.6%, respectively. The obtained results show that the DRS is a promising noninvasive optical technique for detection and classification of malignant and benign canine skin and subcutaneous tumors. The method should be further investigated on tumors with common origin.

Paper Details

Date Published: 9 March 2015
PDF: 9 pages
J. Biomed. Opt. 20(3) 037003 doi: 10.1117/1.JBO.20.3.037003
Published in: Journal of Biomedical Optics Volume 20, Issue 3
Show Author Affiliations
Blaž Cugmas, Univ. of Ljubljana (Slovenia)
Sensum d.o.o. (Slovenia)
Tanja Plavec, Univ. of Ljubljana (Slovenia)
Maksimilijan Bregar, Univ. of Ljubljana (Slovenia)
Peter Naglič, Univ. of Ljubljana (Slovenia)
Franjo Pernuš, Univ. of Ljubljana (Slovenia)
Sensum d.o.o. (Slovenia)
Boštjan Likar, Univ. of Ljubljana (Slovenia)
Sensum d.o.o. (Slovenia)
Miran Bürmen, Univ. of Ljubljana (Slovenia)
Sensum d.o.o. (Slovenia)


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