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Journal of Biomedical Optics • Open Access

Diagnose human colonic tissues by terahertz near-field imaging
Author(s): Hua Chen; Shi Hua Ma; Xiumei Wu; Wenxing Yang; Tian Zhao

Paper Abstract

Based on a terahertz (THz) pipe-based near-field imaging system, we demonstrate the capability of THz imaging to diagnose freshly surgically excised human colonic tissues. Through THz near-field scanning the absorbance of the colonic tissues, the acquired images can clearly distinguish cancerous tissues from healthy tissues fast and automatically without pathological hematoxylin and eosin stain diagnosis. A statistical study on 58 specimens (20 healthy tissues and 38 tissues with tumor) from 31 patients (mean age: 59 years; range: 46 to 79 years) shows that the corresponding diagnostic sensitivity and specificity on colonic tissues are both 100%. Due to its capability to perform quantitative analysis, our study indicates the potential of the THz pipe-based near-field imaging for future automation on human tumor pathological examinations.

Paper Details

Date Published: 27 March 2015
PDF: 4 pages
J. Biomed. Opt. 20(3) 036017 doi: 10.1117/1.JBO.20.3.036017
Published in: Journal of Biomedical Optics Volume 20, Issue 3
Show Author Affiliations
Hua Chen, Southeast Univ. (China)
Shi Hua Ma, Southeast Univ. (China)
Xiumei Wu, Southeast Univ. (China)
Wenxing Yang, Southeast Univ. (China)
Tian Zhao, Southeast Univ. (China)

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