Share Email Print
cover

Journal of Biomedical Optics

Second derivative multispectral algorithm for quantitative assessment of cutaneous tissue oxygenation
Author(s): Jiwei Huang; Shiwu Zhang; Surya Gnyawali; Chandan K. Sen; Ronald X. Xu
Format Member Price Non-Member Price
PDF $20.00 $25.00

Paper Abstract

We report a second derivative multispectral algorithm for quantitative assessment of cutaneous tissue oxygen saturation (StO2). The algorithm is based on a forward model of light transport in multilayered skin tissue and an inverse algorithm for StO2 reconstruction. Based on the forward simulation results, a parameter of a second derivative ratio (SDR) is derived as a function of cutaneous tissue StO2. The SDR function is optimized at a wavelength set of 544, 552, 568, 576, 592, and 600 nm so that cutaneous tissue StO2 can be derived with minimal artifacts by blood concentration, tissue scattering, and melanin concentration. The proposed multispectral StO2 imaging algorithm is verified in both benchtop and in vivo experiments. The experimental results show that the proposed multispectral imaging algorithm is able to map cutaneous tissue StO2 in high temporal resolution with reduced measurement artifacts induced by different skin conditions in comparison with other three commercial tissue oxygen measurement systems. These results indicate that the multispectral StO2 imaging technique has the potential for noninvasive and quantitative assessment of skin tissue oxygenation with a high temporal resolution.

Paper Details

Date Published: 2 March 2015
PDF: 12 pages
J. Biomed. Opt. 20(3) 036001 doi: 10.1117/1.JBO.20.3.036001
Published in: Journal of Biomedical Optics Volume 20, Issue 3
Show Author Affiliations
Jiwei Huang, The Ohio State Univ. (United States)
Shiwu Zhang, Univ. of Science and Technology of China (China)
Surya Gnyawali, The Ohio State Univ. (United States)
Chandan K. Sen, The Ohio State Univ. (United States)
Ronald X. Xu, The Ohio State Univ. (United States)
Univ. of Science and Technology of China (China)


© SPIE. Terms of Use
Back to Top