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Journal of Biomedical Optics • Open Access

Monte Carlo modeling of light propagation in the human head for applications in sinus imaging
Author(s): Albert E. Cerussi; Nikhil Mishra; Joon You; Naveen Bhandarkar; Brian Wong

Paper Abstract

Sinus blockages are a common reason for physician visits, affecting one out of seven people in the United States, and often require medical treatment. Diagnosis in the primary care setting is challenging because symptom criteria (via detailed clinical history) plus objective imaging [computed tomography (CT) or endoscopy] are recommended. Unfortunately, neither option is routinely available in primary care. We previously demonstrated that low-cost near-infrared (NIR) transillumination correlates with the bulk findings of sinus opacity measured by CT. We have upgraded the technology, but questions of source optimization, anatomical influence, and detection limits remain. In order to begin addressing these questions, we have modeled NIR light propagation inside a three-dimensional adult human head constructed via CT images using a mesh-based Monte Carlo algorithm (MMCLAB). In this application, the sinus itself, which when healthy is a void region (e.g., nonscattering), is the region of interest. We characterize the changes in detected intensity due to clear (i.e., healthy) versus blocked sinuses and the effect of illumination patterns. We ran simulations for two clinical cases and compared simulations with measurements. The simulations presented herein serve as a proof of concept that this approach could be used to understand contrast mechanisms and limitations of NIR sinus imaging.

Paper Details

Date Published: 17 March 2015
PDF: 9 pages
J. Biomed. Opt. 20(3) 035004 doi: 10.1117/1.JBO.20.3.035004
Published in: Journal of Biomedical Optics Volume 20, Issue 3
Show Author Affiliations
Albert E. Cerussi, Beckman Laser Institute and Medical Clinic (United States)
Nikhil Mishra, Beckman Laser Institute and Medical Clinic (United States)
Joon You, Praxis Biosciences (United States)
Naveen Bhandarkar, Univ. of California, Irvine School of Medicine (United States)
Brian Wong, Beckman Laser Institute and Medical Clinic (United States)

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