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Journal of Biomedical Optics

Comparative analysis of combined spectral and optical tomography methods for detection of skin and lung cancers
Author(s): Valery P. Zakharov; Ivan A. Bratchenko; Dmitry N. Artemyev; Oleg O. Myakinin; Dmitry V. Kornilin; Sergey V. Kozlov; Alexander A. Moryatov
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Paper Abstract

Malignant skin tumors of different types were studied in vivo using optical coherence tomography (OCT), backscattering (BS), and Raman spectroscopy (RS). A multimodal method is proposed for early cancer detection based on complex analysis of OCT images by their relative alteration of scattered-radiation spectral intensities between malignant and healthy tissues. An increase in average accuracy of diagnosis was observed for a variety of cancer types (9% sensitivity, 8% specificity) by a multimodal RS-BS-OCT system in comparison with any of the three methods used separately. The proposed approach equalizes the processing rates for all methods and allows for simultaneous imaging and classification of tumors.

Paper Details

Date Published: 4 February 2015
PDF: 8 pages
J. Biomed. Opt. 20(2) 025003 doi: 10.1117/1.JBO.20.2.025003
Published in: Journal of Biomedical Optics Volume 20, Issue 2
Show Author Affiliations
Valery P. Zakharov, Samara State Aerospace Univ. (Russia)
Ivan A. Bratchenko, Samara State Aerospace Univ. (Russia)
Dmitry N. Artemyev, Samara State Aerospace Univ. (Russia)
Oleg O. Myakinin, Samara State Aerospace Univ. (Russia)
Dmitry V. Kornilin, Samara State Aerospace Univ. (Russia)
Sergey V. Kozlov, Samara State Medical Univ. (Russia)
Alexander A. Moryatov, Samara State Medical Univ. (Russia)


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