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Journal of Biomedical Optics

Combined imaging of oxidative stress and microscopic structure reveals new features in human atherosclerotic plaques
Author(s): Magnus B. Lilledahl; Håkan Gustafsson; Pål Gunnar Ellingsen; Helene Zachrisson; Martin Hallbeck; Vegard S. Hagen; Morten Kildemo; Mikael Lindgren
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Paper Abstract

Human atherosclerotic samples collected by carotid endarterectomy were investigated using electronic paramagnetic resonance imaging (EPRI) for visualization of reactive oxygen species, and nonlinear optical microscopy (NLOM) to study structural features. Regions of strong EPRI signal, indicating a higher concentration of reactive oxygen species and increased inflammation, were found to colocalize with regions dense in cholesterol crystals as revealed by NLOM.

Paper Details

Date Published: 25 February 2015
PDF: 3 pages
J. Biomed. Opt. 20(2) 020503 doi: 10.1117/1.JBO.20.2.020503
Published in: Journal of Biomedical Optics Volume 20, Issue 2
Show Author Affiliations
Magnus B. Lilledahl, Norwegian Univ. of Science and Technology (Norway)
Håkan Gustafsson, Linköping Univ. (Sweden)
Pål Gunnar Ellingsen, Norwegian Univ. of Science and Technology (Norway)
Helene Zachrisson, Linköping Univ. (Sweden)
Martin Hallbeck, Linköping Univ. (Sweden)
Vegard S. Hagen, Norwegian Univ. of Science and Technology (Norway)
Morten Kildemo, Norwegian Univ. of Science and Technology (Norway)
Mikael Lindgren, Norwegian Univ. of Science and Technology (Norway)
Linköping University (Sweden)

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