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Journal of Biomedical Optics

Promotion of neural sprouting using low-level green light-emitting diode phototherapy
Author(s): Noa Alon; Hamootal Duadi; Ortal Cohen; Tamar Samet; Neta Zilony; Hadas Schori; Orit Shefi; Zeev Zalevsky
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Paper Abstract

We irradiated neuroblastoma SH-SY5Y cell line with low-level light-emitting diode (LED) illumination at a visible wavelength of 520 nm (green) and intensity of 100  mW/cm2. We captured and analyzed the cell morphology before LED treatment, immediately after, and 12 and 24 h after treatment. Our study demonstrated that LED illumination increases the amount of sprouting dendrites in comparison to the control untreated cells. This treatment also resulted in more elongated cells after treatment in comparison to the control cells and higher levels of expression of a differentiation related gene. This result is a good indication that the proposed method could serve in phototherapy treatment for increasing sprouting and enhancing neural network formation.

Paper Details

Date Published: 4 February 2015
PDF: 3 pages
J. Biomed. Opt. 20(2) 020502 doi: 10.1117/1.JBO.20.2.020502
Published in: Journal of Biomedical Optics Volume 20, Issue 2
Show Author Affiliations
Noa Alon, Bar-Ilan Univ. (Israel)
Hamootal Duadi, Bar-Ilan Univ. (Israel)
Ortal Cohen, Bar-Ilan Univ. (Israel)
Tamar Samet, Bar-Ilan Univ. (Israel)
Neta Zilony, Bar-Ilan Univ. (Israel)
Hadas Schori, Bar-Ilan Univ. (Israel)
Orit Shefi, Bar-Ilan Univ. (Israel)
Zeev Zalevsky, Bar-Ilan Univ. (Israel)

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