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Journal of Biomedical Optics • Open Access

Quantitative assessment of corneal viscoelasticity using optical coherence elastography and a modified Rayleigh–Lamb equation
Author(s): Zhaolong Han; Salavat R. Aglyamov; Jiasong Li; Manmohan Singh; Shang Wang; Srilatha Vantipalli; Chen Wu; Chih-hao Liu; Michael D. Twa; Kirill V. Larin

Paper Abstract

We demonstrate the use of a modified Rayleigh–Lamb frequency equation in conjunction with noncontact optical coherence elastography to quantify the viscoelastic properties of the cornea. Phase velocities of air-pulse-induced elastic waves were extracted by spectral analysis and used for calculating the Young’s moduli of the samples using the Rayleigh–Lamb frequency equation (RLFE). Validation experiments were performed on 2% agar phantoms (n=3) and then applied to porcine corneas (n=3) in situ. The Young’s moduli of the porcine corneas were estimated to be ∼60  kPa with a shear viscosity ∼0.33  Pa·s. The results demonstrate that the RLFE is a promising method for noninvasive quantification of the corneal biomechanical properties and may potentially be useful for clinical ophthalmological applications.

Paper Details

Date Published: 3 February 2015
PDF: 3 pages
J. Biomed. Opt. 20(2) 020501 doi: 10.1117/1.JBO.20.2.020501
Published in: Journal of Biomedical Optics Volume 20, Issue 2
Show Author Affiliations
Zhaolong Han, Univ. of Houston (United States)
Salavat R. Aglyamov, The Univ. of Texas at Austin (United States)
Jiasong Li, Univ. of Houston (United States)
Manmohan Singh, Univ. of Houston (United States)
Shang Wang, Univ. of Houston (United States)
Baylor College of Medicine (United States)
Srilatha Vantipalli, Univ. of Houston (United States)
Chen Wu, Univ. of Houston (United States)
Chih-hao Liu, Univ. of Houston (United States)
Michael D. Twa, Univ. of Alabama (United States)
Kirill V. Larin, Univ. of Houston (United States)
Baylor College of Medicine (United States)

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