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Journal of Biomedical Optics • Open Access

Miniature probe for the delivery and monitoring of a photopolymerizable material
Author(s): Andreas Schmocker; Azadeh Khoushabi; Constantin Schizas; Pierre-Etienne Bourban; Dominique P. Pioletti; Christophe Moser

Paper Abstract

Photopolymerization is a common method to cure materials initially in a liquid state, such as dental implants or bone or tissue fillers. Recent advances in the development of biocompatible gel- and cement-systems open up an avenue for in situ photopolymerization. For minimally invasive surgery, such procedures require miniaturized surgical endoscopic probes to activate and control photopolymerization in situ. We present a miniaturized light probe in which a photoactive material can be (1) mixed, pressurized, and injected, (2) photopolymerized/photoactivated, and (3) monitored during the chemical reaction. The device is used to implant and cure poly(ethylene glycol) dimethacrylate-hydrogel-precursor in situ with ultraviolet A (UVA) light (365 nm) while the polymerization reaction is monitored in real time by collecting the fluorescence and Raman signals generated by the 532-nm excitation light source. Hydrogels could be delivered, photopolymerized, and monitored by the probe up to a curing depth of 4 cm. The size of the photopolymerized samples could be correlated to the fluorescent signal collected by the probe, and the reproducibility of the procedure could be demonstrated. The position of the probe tip inside a bovine caudal intervertebral disc could be estimated in vitro based on the collected fluorescence and Raman signal.

Paper Details

Date Published: 10 December 2015
PDF: 8 pages
J. Biomed. Opt. 20(12) 127001 doi: 10.1117/1.JBO.20.12.127001
Published in: Journal of Biomedical Optics Volume 20, Issue 12
Show Author Affiliations
Andreas Schmocker, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Azadeh Khoushabi, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Constantin Schizas, Clinique Cecil (Switzerland)
Pierre-Etienne Bourban, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Dominique P. Pioletti, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Christophe Moser, Ecole Polytechnique Fédérale de Lausanne (Switzerland)

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