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Journal of Biomedical Optics

Visualizing biofilm formation in endotracheal tubes using endoscopic three-dimensional optical coherence tomography
Author(s): Andrew E. Heidari; Samer Moghaddam; Kimberly K. Truong; Li-Dek Chou; Carl Genberg; Matthew Brenner; Zhongping Chen
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Paper Abstract

Biofilm formation has been linked to ventilator-associated pneumonia, which is a prevalent infection in hospital intensive care units. Currently, there is no rapid diagnostic tool to assess the degree of biofilm formation or cellular biofilm composition. Optical coherence tomography (OCT) is a minimally invasive, nonionizing imaging modality that can be used to provide high-resolution cross-sectional images. Biofilm deposited in critical care patients’ endotracheal tubes was analyzed <italic<in vitro</italic<. This study demonstrates that OCT could potentially be used as a diagnostic tool to analyze and assess the degree of biofilm formation and extent of airway obstruction caused by biofilm in endotracheal tubes.

Paper Details

Date Published: 22 December 2015
PDF: 4 pages
J. Biomed. Opt. 20(12) 126010 doi: 10.1117/1.JBO.20.12.126010
Published in: Journal of Biomedical Optics Volume 20, Issue 12
Show Author Affiliations
Andrew E. Heidari, Univ. of California, Irvine (United States)
Beckman Laser Institute and Medical Clinic (United States)
Samer Moghaddam, Univ. of California, Irvine (United States)
Kimberly K. Truong, Univ. of California, Irvine (United States)
Li-Dek Chou, Beckman Laser Institute and Medical Clinic (United States)
Carl Genberg, N8 Medical, Inc. (United States)
Matthew Brenner, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)
Zhongping Chen, Univ. of California, Irvine (United States)
Beckman Laser Institute and Medical Clinic (United States)


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