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Journal of Biomedical Optics • Open Access

Three-dimensional fuse deposition modeling of tissue-simulating phantom for biomedical optical imaging
Author(s): Erbao Dong; Zuhua Zhao; Minjie Wang; Yanjun Xie; Shidi Li; Pengfei Shao; Liuquan Cheng; Ronald X. Xu

Paper Abstract

Biomedical optical devices are widely used for clinical detection of various tissue anomalies. However, optical measurements have limited accuracy and traceability, partially owing to the lack of effective calibration methods that simulate the actual tissue conditions. To facilitate standardized calibration and performance evaluation of medical optical devices, we develop a three-dimensional fuse deposition modeling (FDM) technique for freeform fabrication of tissue-simulating phantoms. The FDM system uses transparent gel wax as the base material, titanium dioxide (TiO2) powder as the scattering ingredient, and graphite powder as the absorption ingredient. The ingredients are preheated, mixed, and deposited at the designated ratios layer-by-layer to simulate tissue structural and optical heterogeneities. By printing the sections of human brain model based on magnetic resonance images, we demonstrate the capability for simulating tissue structural heterogeneities. By measuring optical properties of multilayered phantoms and comparing with numerical simulation, we demonstrate the feasibility for simulating tissue optical properties. By creating a rat head phantom with embedded vasculature, we demonstrate the potential for mimicking physiologic processes of a living system.

Paper Details

Date Published: 25 November 2015
PDF: 10 pages
J. Biomed. Opt. 20(12) 121311 doi: 10.1117/1.JBO.20.12.121311
Published in: Journal of Biomedical Optics Volume 20, Issue 12
Show Author Affiliations
Erbao Dong, Univ. of Science and Technology of China (China)
Zuhua Zhao, Univ. of Science and Technology of China (China)
Minjie Wang, Univ. of Science and Technology of China (China)
Yanjun Xie, Univ. of Science and Technology of China (China)
Shidi Li, Univ. of Science and Technology of China (China)
Pengfei Shao, Univ. of Science and Technology of China (China)
Liuquan Cheng, Chinese PLA General Hospital (China)
Ronald X. Xu, Univ. of Science and Technology of China (China)
The Ohio State Univ. (United States)

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