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Journal of Biomedical Optics • Open Access

Sub‐40 fs, 1060‐nm Yb‐fiber laser enhances penetration depth in nonlinear optical microscopy of human skin
Author(s): Mihaela Balu; Ilyas Saytashev; Jue Hou; Marcos Dantus; Bruce J. Tromberg

Paper Abstract

Advancing the practical utility of nonlinear optical microscopy requires continued improvement in imaging depth and contrast. We evaluated second‐harmonic generation (SHG) and third‐harmonic generation images from ex vivo human skin and showed that a sub‐40 fs, 1060‐nm Yb‐fiber laser can enhance SHG penetration depth by up to 80% compared to a <100  fs, 800 nm Ti:sapphire source. These results demonstrate the potential of fiber‐based laser systems to address a key performance limitation related to nonlinear optical microscopy (NLOM) technology while providing a low‐barrier‐to‐access alternative to Ti:sapphire sources that could help accelerate the movement of NLOM into clinical practice.

Paper Details

Date Published: 7 December 2015
PDF: 4 pages
J. Biomed. Opt. 20(12) 120501 doi: 10.1117/1.JBO.20.12.120501
Published in: Journal of Biomedical Optics Volume 20, Issue 12
Show Author Affiliations
Mihaela Balu, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)
Ilyas Saytashev, Michigan State Univ. (United States)
Jue Hou, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)
Marcos Dantus, Michigan State Univ. (United States)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)


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