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Journal of Biomedical Optics • Open Access

Whole blood glucose analysis based on smartphone camera module
Author(s): Jasmine P. Devadhasan; Hyunhee Oh; Cheol Soo Choi; Sanghyo Kim

Paper Abstract

Complementary metal oxide semiconductor (CMOS) image sensors have received great attention for their high efficiency in biological applications. The present work describes a CMOS image sensor-based whole blood glucose monitoring system through a point-of-care (POC) approach. A simple poly-ethylene terephthalate (PET) chip was developed to carry out the enzyme kinetic reaction at various concentrations (110–586  mg/dL) of mouse blood glucose. In this technique, assay reagent is immobilized onto amine functionalized silica (AFSiO2) nanoparticles as an electrostatic attraction in order to achieve glucose oxidation on the chip. The assay reagent immobilized AFSiO2 nanoparticles develop a semi-transparent reaction platform, which is technically a suitable chip to analyze by a camera module. The oxidized glucose then produces a green color according to the glucose concentration and is analyzed by the camera module as a photon detection technique; the photon number decreases when the glucose concentration increases. The combination of these components, the CMOS image sensor and enzyme immobilized PET film chip, constitute a compact, accurate, inexpensive, precise, digital, highly sensitive, specific, and optical glucose-sensing approach for POC diagnosis.

Paper Details

Date Published: 2 November 2015
PDF: 10 pages
J. Biomed. Opt. 20(11) 117001 doi: 10.1117/1.JBO.20.11.117001
Published in: Journal of Biomedical Optics Volume 20, Issue 11
Show Author Affiliations
Jasmine P. Devadhasan, Gachon Univ. (Korea, Republic of)
Hyunhee Oh, Gachon Univ. (Korea, Republic of)
Cheol Soo Choi, Gachon Medical Research Institute (Korea, Republic of)
Sanghyo Kim, Gachon Univ. (Korea, Republic of)

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