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Journal of Biomedical Optics • Open Access

Detecting structural information of scatterers using spatial frequency domain imaging
Author(s): Nico Bodenschatz; Philipp Krauter; Steffen Nothelfer; Florian Foschum; Florian Bergmann; André Liemert; Alwin Kienle

Paper Abstract

We demonstrate optical phantom experiments on the phase function parameter γ using spatial frequency domain imaging. The incorporation of two different types of scattering particles allows for control of the optical phantoms’ microscopic scattering properties. By laterally structuring areas with either TiO2 or Al2O3 scattering particles, we were able to obtain almost pure subdiffusive scattering contrast in a single optical phantom. Optical parameter mapping was then achieved using an analytical radiative transfer model revealing the microscopic structural contrast on a macroscopic field of view. As part of our study, we explain several correction and referencing techniques for high spatial frequency analysis and experimentally study the sampling depth of the subdiffusive parameter γ.

Paper Details

Date Published: 23 November 2015
PDF: 7 pages
J. Biomed. Opt. 20(11) 116006 doi: 10.1117/1.JBO.20.11.116006
Published in: Journal of Biomedical Optics Volume 20, Issue 11
Show Author Affiliations
Nico Bodenschatz, Institut für Lasertechnologien in der Medizin und Messtechnik (Germany)
Philipp Krauter, Institut für Lasertechnologien in der Medizin und Messtechnik (Germany)
Steffen Nothelfer, Institut für Lasertechnologien in der Medizin und Messtechnik (Germany)
Florian Foschum, Institut für Lasertechnologien in der Medizin und Messtechnik (Germany)
Florian Bergmann, Institut für Lasertechnologien in der Medizin und Messtechnik (Germany)
André Liemert, Institut für Lasertechnologien in der Medizin und Messtechnik (Germany)
Alwin Kienle, Institut für Lasertechnologien in der Medizin und Messtechnik (Germany)


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