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Journal of Biomedical Optics • Open Access

Statistical analysis of motion contrast in optical coherence tomography angiography
Author(s): Yuxuan Cheng; Li Guo; Cong Pan; Tongtong Lu; Tianyu Hong; Zhihua Ding; Peng Li

Paper Abstract

Optical coherence tomography angiography (Angio-OCT), mainly based on the temporal dynamics of OCT scattering signals, has found a range of potential applications in clinical and scientific research. Based on the model of random phasor sums, temporal statistics of the complex-valued OCT signals are mathematically described. Statistical distributions of the amplitude differential and complex differential Angio-OCT signals are derived. The theories are validated through the flow phantom and live animal experiments. Using the model developed, the origin of the motion contrast in Angio-OCT is mathematically explained, and the implications in the improvement of motion contrast are further discussed, including threshold determination and its residual classification error, averaging method, and scanning protocol. The proposed mathematical model of Angio-OCT signals can aid in the optimal design of the system and associated algorithms.

Paper Details

Date Published: 2 November 2015
PDF: 10 pages
J. Biomed. Opt. 20(11) 116004 doi: 10.1117/1.JBO.20.11.116004
Published in: Journal of Biomedical Optics Volume 20, Issue 11
Show Author Affiliations
Yuxuan Cheng, Zhejiang Univ. (China)
Li Guo, Zhejiang Univ. (China)
Cong Pan, Zhejiang Univ. (China)
Tongtong Lu, Zhejiang Univ. (China)
Tianyu Hong, Zhejiang Univ. (China)
Zhihua Ding, Zhejiang Univ. (China)
Peng Li, Zhejiang Univ. (China)

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