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Journal of Biomedical Optics • Open Access

Bessel-beam Grueneisen relaxation photoacoustic microscopy with extended depth of field
Author(s): Junhui Shi; Lidai Wang; Cedric Noordam; Lihong V. Wang

Paper Abstract

The short focal depth of a Gaussian beam limits the volumetric imaging speed of optical resolution photoacoustic microscopy (OR-PAM). A Bessel beam, which is diffraction free, provides a long focal depth, but its side lobes deteriorate image quality when the Bessel beam is directly employed to excite photoacoustic (PA) signals in OR-PAM. We present a nonlinear approach based on the Grueneisen relaxation effect to suppress the side-lobe artifacts in PA imaging. This method extends the focal depth of OR-PAM and speeds up volumetric imaging. We experimentally demonstrated a 1-mm focal depth with a 7-μm lateral resolution and volumetrically imaged a carbon fiber and red blood cell samples.

Paper Details

Date Published: 2 November 2015
PDF: 6 pages
J. Biomed. Opt. 20(11) 116002 doi: 10.1117/1.JBO.20.11.116002
Published in: Journal of Biomedical Optics Volume 20, Issue 11
Show Author Affiliations
Junhui Shi, Washington Univ. in St. Louis (United States)
Lidai Wang, Washington Univ. in St. Louis (United States)
City Univ. of Hong Kong (China)
Cedric Noordam, Washington Univ. in St. Louis (United States)
Univ. Twente (The Netherlands)
Lihong V. Wang, Washington Univ. in St. Louis (United States)

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