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Journal of Biomedical Optics

Oral cancer screening: serum Raman spectroscopic approach
Author(s): Aditi Sahu; Suyash Dhoot; Amandeep Singh; Sharada Sawant; Nikhila Nandakumar; Sneha Talathi-Desai; Mandavi Garud; Sandeep Pagare; Sanjeeva Srivastava; Sudhir Nair; Pankaj Chaturvedi; C. Murali Krishna
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Paper Abstract

Serum Raman spectroscopy (RS) has previously shown potential in oral cancer diagnosis and recurrence prediction. To evaluate the potential of serum RS in oral cancer screening, premalignant and cancer-specific detection was explored in the present study using 328 subjects belonging to healthy controls, premalignant, disease controls, and oral cancer groups. Spectra were acquired using a Raman microprobe. Spectral findings suggest changes in amino acids, lipids, protein, DNA, and β-carotene across the groups. A patient-wise approach was employed for data analysis using principal component linear discriminant analysis. In the first step, the classification among premalignant, disease control (nonoral cancer), oral cancer, and normal samples was evaluated in binary classification models. Thereafter, two screening-friendly classification approaches were explored to further evaluate the clinical utility of serum RS: a single four-group model and normal versus abnormal followed by determining the type of abnormality model. Results demonstrate the feasibility of premalignant and specific cancer detection. The normal versus abnormal model yields better sensitivity and specificity rates of 64 and 80%; these rates are comparable to standard screening approaches. Prospectively, as the current screening procedure of visual inspection is useful mainly for high-risk populations, serum RS may serve as a useful adjunct for early and specific detection of oral precancers and cancer.

Paper Details

Date Published: 17 November 2015
PDF: 11 pages
J. Biomed. Opt. 20(11) 115006 doi: 10.1117/1.JBO.20.11.115006
Published in: Journal of Biomedical Optics Volume 20, Issue 11
Show Author Affiliations
Aditi Sahu, Advanced Ctr. for Treatment, Research & Education in Cancer (India)
Suyash Dhoot, Indian Institute of Technology Bombay (India)
Amandeep Singh, D. Y. Patil Dental College (India)
Sharada Sawant, Advanced Ctr. for Treatment, Research & Education in Cancer (India)
Nikhila Nandakumar, Advanced Ctr. for Treatment, Research & Education in Cancer (India)
Sneha Talathi-Desai, Advanced Ctr. for Treatment, Research & Education in Cancer (India)
Mandavi Garud, D. Y. Patil Dental College (India)
Sandeep Pagare, D. Y. Patil Dental College (India)
Sanjeeva Srivastava, Indian Institute of Technology Bombay (India)
Sudhir Nair, Tata Memorial Ctr. (India)
Pankaj Chaturvedi, Tata Memorial Hospital (India)
C. Murali Krishna, Advanced Ctr. for Treatment, Research & Education in Cancer (India)


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