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Journal of Biomedical Optics

Holographic analysis on deformation and restoration of malaria-infected red blood cells by antimalarial drug
Author(s): Hyeokjun Byeon; Young-Ran Ha; Sang-Joon Lee
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Paper Abstract

Malaria parasites induce morphological, biochemical, and mechanical changes in red blood cells (RBCs). Mechanical variations are closely related to the deformability of individual RBCs. The deformation of various RBCs, including healthy and malaria-infected RBCs (iRBCs), can be directly observed through quantitative phase imaging (QPI). The effects of chloroquine treatment on the mechanical property variation of iRBCs were investigated using time-resolved holographic QPI of single live cells on a millisecond time scale. The deformabilities of healthy RBCs, iRBCs, and drug-treated iRBCs were compared, and the effect of chloroquine on iRBC restoration was experimentally examined. The present results are beneficial to elucidate the dynamic characteristics of iRBCs and the effect of the antimalarial drug on iRBCs.

Paper Details

Date Published: 6 November 2015
PDF: 7 pages
J. Biomed. Opt. 20(11) 115003 doi: 10.1117/1.JBO.20.11.115003
Published in: Journal of Biomedical Optics Volume 20, Issue 11
Show Author Affiliations
Hyeokjun Byeon, Pohang Univ. of Science and Technology (Republic of Korea)
Young-Ran Ha, Pohang Univ. of Science and Technology (Republic of Korea)
Sang-Joon Lee, Pohang Univ. of Science and Technology (Korea, Republic of)

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