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Journal of Biomedical Optics

Monitoring photodynamic therapy with photoacoustic microscopy
Author(s): Peng Shao; David W. Chapman; Ronald B. Moore; Roger J. Zemp
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Paper Abstract

We present our work on examining the feasibility of monitoring photodynamic therapy (PDT)-induced vasculature change with acoustic-resolution photoacoustic microscopy (PAM). Verteporfin, an FDA-approved photosensitizer for clinical PDT, was utilized. With a 60-μm-resolution PAM system, we demonstrated the capability of PAM to monitor PDT-induced vasculature variations in a chick chorioallantoic membrane model with topical application and in a rat ear with intravenous injection of the photosensitizer. We also showed oxygen saturation change in target blood vessels due to PDT. Success of the present approach may potentially lead to the application of PAM imaging in evaluating PDT efficacy, guiding treatment, and predicting responders from nonresponders.

Paper Details

Date Published: 28 October 2015
PDF: 6 pages
J. Biomed. Opt. 20(10) 106012 doi: 10.1117/1.JBO.20.10.106012
Published in: Journal of Biomedical Optics Volume 20, Issue 10
Show Author Affiliations
Peng Shao, University of Alberta (Canada)
David W. Chapman, Univ. of Alberta (Canada)
Ronald B. Moore, Univ. of Alberta (Canada)
Roger J. Zemp, Univ. of Alberta (Canada)


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