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Journal of Biomedical Optics

All-plastic miniature fluorescence microscope for point-of-care readout of bead-based bioassays
Author(s): Alessandra Forcucci; Michal Emanuel Pawlowski; Zachary Crannell; Ina Pavlova; Rebecca Richards-Kortum; Tomasz S. Tkaczyk
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Paper Abstract

A number of new platforms have been developed for multiplexed bioassays that rely on imaging targeted fluorescent beads labeled with different fluorescent dyes. We developed a compact, low-cost three-dimensional printed fluorescence microscope that can be used as a detector for mutiplexed, bead-based assays to support point-of-care applications. Images obtained with the microscope were analyzed to differentiate multiple analytes in a single sample with a comparable limit of detection to commercially available macroscopic assay platforms.

Paper Details

Date Published: 21 October 2015
PDF: 14 pages
J. Biomed. Opt. 20(10) 105010 doi: 10.1117/1.JBO.20.10.105010
Published in: Journal of Biomedical Optics Volume 20, Issue 10
Show Author Affiliations
Alessandra Forcucci, Rice Univ. (United States)
Michal Emanuel Pawlowski, Rice Univ. (United States)
Zachary Crannell, Rice Univ. (United States)
Ina Pavlova, Rice Univ. (United States)
Rebecca Richards-Kortum, Rice Univ. (United States)
Tomasz S. Tkaczyk, Rice Univ. (United States)

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