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Journal of Biomedical Optics

Diffuse photon density wave measurements and Monte Carlo simulations
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Paper Abstract

Diffuse photon density wave (DPDW) methodology is widely used in a number of biomedical applications. Here, we present results of Monte Carlo simulations that employ an effective numerical procedure based upon a description of radiative transfer in terms of the Bethe–Salpeter equation. A multifrequency noncontact DPDW system was used to measure aqueous solutions of intralipid at a wide range of source–detector separation distances, at which the diffusion approximation of the radiative transfer equation is generally considered to be invalid. We find that the signal–noise ratio is larger for the considered algorithm in comparison with the conventional Monte Carlo approach. Experimental data are compared to the Monte Carlo simulations using several values of scattering anisotropy and to the diffusion approximation. Both the Monte Carlo simulations and diffusion approximation were in very good agreement with the experimental data for a wide range of source–detector separations. In addition, measurements with different wavelengths were performed to estimate the size and scattering anisotropy of scatterers.

Paper Details

Date Published: 14 October 2015
PDF: 9 pages
J. Biomed. Opt. 20(10) 105006 doi: 10.1117/1.JBO.20.10.105006
Published in: Journal of Biomedical Optics Volume 20, Issue 10
Show Author Affiliations
Vladimir L. Kuzmin, Saint Petersburg State Univ. (Russia)
St. Petersburg State Univ. of Trade and Economics (Russia)
Michael T. Neidrauer, Drexel Univ. (United States)
David Diaz, Drexel Univ. (United States)
Leonid A. Zubkov, Drexel Univ. (United States)

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