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Journal of Biomedical Optics

Nonlinear approach to difference imaging in diffuse optical tomography
Author(s): Meghdoot Mozumder; Tanja Tarvainen; Aku Seppänen; Ilkka Nissilä; Simon R. Arridge; Ville Kolehmainen
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Paper Abstract

Difference imaging aims at recovery of the change in the optical properties of a body based on measurements before and after the change. Conventionally, the image reconstruction is based on using difference of the measurements and a linear approximation of the observation model. One of the main benefits of the linearized difference reconstruction is that the approach has a good tolerance to modeling errors, which cancel out partially in the subtraction of the measurements. However, a drawback of the approach is that the difference images are usually only qualitative in nature and their spatial resolution can be weak because they rely on the global linearization of the nonlinear observation model. To overcome the limitations of the linear approach, we investigate a nonlinear approach for difference imaging where the images of the optical parameters before and after the change are reconstructed simultaneously based on the two datasets. We tested the feasibility of the method with simulations and experimental data from a phantom and studied how the approach tolerates modeling errors like domain truncation, optode coupling errors, and domain shape errors.

Paper Details

Date Published: 6 October 2015
PDF: 12 pages
J. Biomed. Opt. 20(10) 105001 doi: 10.1117/1.JBO.20.10.105001
Published in: Journal of Biomedical Optics Volume 20, Issue 10
Show Author Affiliations
Meghdoot Mozumder, Univ. of Eastern Finland (Finland)
Tanja Tarvainen, Univ. of Eastern Finland (Finland)
Univ. College London (United Kingdom)
Aku Seppänen, Univ. of Eastern Finland (Finland)
Ilkka Nissilä, Aalto Univ. (Finland)
Helsinki Univ. Central Hospital (Finland)
Simon R. Arridge, Univ. College London (United Kingdom)
Ville Kolehmainen, Univ. of Eastern Finland (Finland)

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