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Journal of Biomedical Optics

In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography
Author(s): Li Lin; Jun Xia; Terence T. W. Wong; Lei Li; Lihong V. Wang
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Paper Abstract

Using internal illumination with an optical fiber in the oral cavity, we demonstrate, for the first time, photoacoustic computed tomography (PACT) of the deep brain of rats in vivo. The experiment was performed on a full-ring-array PACT system, with the capability of providing high-speed cross-sectional imaging of the brain. Compared with external illumination through the cranial skull, internal illumination delivers more light to the base of the brain. Consequently, in vivo photoacoustic images clearly reveal deep brain structures such as the hypothalamus, brain stem, and cerebral medulla.

Paper Details

Date Published: 22 January 2015
PDF: 4 pages
J. Biomed. Opt. 20(1) 016019 doi: 10.1117/1.JBO.20.1.016019
Published in: Journal of Biomedical Optics Volume 20, Issue 1
Show Author Affiliations
Li Lin, Washington Univ. in St. Louis (United States)
Jun Xia, Washington Univ. in St. Louis (United States)
Univ. at Buffalo (United States)
Terence T. W. Wong, Washington Univ. in St. Louis (United States)
Lei Li, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)

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