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Journal of Biomedical Optics

Image overlay solution based on threshold detection for a compact near infrared fluorescence goggle system
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Paper Abstract

Near infrared (NIR) fluorescence imaging has shown great potential for various clinical procedures, including intraoperative image guidance. However, existing NIR fluorescence imaging systems either have a large footprint or are handheld, which limits their usage in intraoperative applications. We present a compact NIR fluorescence imaging system (NFIS) with an image overlay solution based on threshold detection, which can be easily integrated with a goggle display system for intraoperative guidance. The proposed NFIS achieves compactness, light weight, hands-free operation, high-precision superimposition, and a real-time frame rate. In addition, the miniature and ultra-lightweight light-emitting diode tracking pod is easy to incorporate with NIR fluorescence imaging. Based on experimental evaluation, the proposed NFIS solution has a lower detection limit of 25 nM of indocyanine green at 27 fps and realizes a highly precise image overlay of NIR and visible images of mice <italic<in vivo</italic<. The overlay error is limited within a 2-mm scale at a 65-cm working distance, which is highly reliable for clinical study and surgical use.

Paper Details

Date Published: 20 January 2015
PDF: 9 pages
J. Biomed. Opt. 20(1) 016018 doi: 10.1117/1.JBO.20.1.016018
Published in: Journal of Biomedical Optics Volume 20, Issue 1
Show Author Affiliations
Shengkui Gao, Washington Univ. in St. Louis (United States)
Suman B. Mondal, Washington Univ. in St. Louis (United States)
Nan Zhu, College of Optical Sciences, The Univ. of Arizona (United States)
RongGuang Liang, College of Optical Sciences, The Univ. of Arizona (United States)
Samuel Achilefu, Washington Univ. School of Medicine in St. Louis (United States)
Viktor Gruev, Washington Univ. in St. Louis (United States)


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