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Journal of Biomedical Optics

Use of hyperspectral imaging technology to develop a diagnostic support system for gastric cancer
Author(s): Atsushi Goto; Jun Nishikawa; Shu Kiyotoki; Munetaka Nakamura; Junichi Nishimura; Takeshi Okamoto; Hiroyuki Ogihara; Yusuke Fujita; Yoshihiko Hamamoto; Isao Sakaida
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Paper Abstract

Hyperspectral imaging (HSI) is a new technology that obtains spectroscopic information and renders it in image form. This study examined the difference in the spectral reflectance (SR) of gastric tumors and normal mucosa recorded with a hyperspectral camera equipped with HSI technology and attempted to determine the specific wavelength that is useful for the diagnosis of gastric cancer. A total of 104 gastric tumors removed by endoscopic submucosal dissection from 96 patients at Yamaguchi University Hospital were recorded using a hyperspectral camera. We determined the optimal wavelength and the cut-off value for differentiating tumors from normal mucosa to establish a diagnostic algorithm. We also attempted to highlight tumors by image processing using the hyperspectral camera’s analysis software. A wavelength of 770 nm and a cut-off value of 1/4 the corrected SR were selected as the respective optimal wavelength and cut-off values. The rates of sensitivity, specificity, and accuracy of the algorithm’s diagnostic capability were 71%, 98%, and 85%, respectively. It was possible to enhance tumors by image processing at the 770-nm wavelength. HSI can be used to measure the SR in gastric tumors and to differentiate between tumorous and normal mucosa.

Paper Details

Date Published: 20 January 2015
PDF: 6 pages
J. Biomed. Opt. 20(1) 016017 doi: 10.1117/1.JBO.20.1.016017
Published in: Journal of Biomedical Optics Volume 20, Issue 1
Show Author Affiliations
Atsushi Goto, Yamaguchi University Graduate School of Medicine (Japan)
Jun Nishikawa, Yamaguchi Univ. Graduate School of Medicine (Japan)
Shu Kiyotoki, Yamaguchi Univ. Graduate School of Medicine (Japan)
Munetaka Nakamura, Yamaguchi Univ. Graduate School of Medicine (Japan)
Junichi Nishimura, Yamaguchi Univ. Graduate School of Medicine (Japan)
Takeshi Okamoto, Yamaguchi Univ. Graduate School of Medicine (Japan)
Hiroyuki Ogihara, Yamaguchi Univ. Graduate School of Medicine (Japan)
Yusuke Fujita, Yamaguchi Univ. Graduate School of Medicine (Japan)
Yoshihiko Hamamoto, Yamaguchi Univ. Graduate School of Medicine (Japan)
Isao Sakaida, Yamaguchi Univ. Graduate School of Medicine (Japan)


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