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Journal of Biomedical Optics

Multimodal imaging of cutaneous wound tissue
Author(s): Shiwu Zhang; Surya Gnyawali; Jiwei Huang; Wenqi Ren; Gayle Gordillo; Chandan K. Sen; Ronald Xu
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Paper Abstract

Quantitative assessment of wound tissue ischemia, perfusion, and inflammation provides critical information for appropriate detection, staging, and treatment of chronic wounds. However, few methods are available for simultaneous assessment of these tissue parameters in a noninvasive and quantitative fashion. We integrated hyperspectral, laser speckle, and thermographic imaging modalities in a single-experimental setup for multimodal assessment of tissue oxygenation, perfusion, and inflammation characteristics. Algorithms were developed for appropriate coregistration between wound images acquired by different imaging modalities at different times. The multimodal wound imaging system was validated in an occlusion experiment, where oxygenation and perfusion maps of a healthy subject’s upper extremity were continuously monitored during a postocclusive reactive hyperemia procedure and compared with standard measurements. The system was also tested in a clinical trial where a wound of three millimeters in diameter was introduced on a healthy subject’s lower extremity and the healing process was continuously monitored. Our <italic<in vivo</italic< experiments demonstrated the clinical feasibility of multimodal cutaneous wound imaging.

Paper Details

Date Published: 20 January 2015
PDF: 7 pages
J. Biomed. Opt. 20(1) 016016 doi: 10.1117/1.JBO.20.1.016016
Published in: Journal of Biomedical Optics Volume 20, Issue 1
Show Author Affiliations
Shiwu Zhang, Univ. of Science and Technology of China (China)
The Ohio State Univ. (United States)
Surya Gnyawali, The Ohio State Univ. (United States)
Jiwei Huang, The Ohio State Univ. (United States)
Wenqi Ren, Univ. of Science and Technology of China (China)
Gayle Gordillo, The Ohio State Univ. (United States)
Chandan K. Sen, The Ohio State Univ. (United States)
Ronald Xu, Univ. of Science and Technology of China (China)
The Ohio State Univ. (United States)

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