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Journal of Biomedical Optics • Open Access

Analysis of optimum conditions of depolarization imaging by polarization-sensitive optical coherence tomography in the human retina
Author(s): Mitsuro Sugita; Michael Pircher; Stefan Zotter; Bernhard Baumann; Kenichi Saito; Tomoyuki Makihira; Nobuhiro Tomatsu; Makoto Sato; Christoph K. Hitzenberger

Paper Abstract

Measurement and imaging of depolarization by polarization-sensitive optical coherence tomography (PS-OCT) requires averaging of Stokes vector elements within two- or three-dimensional (3-D) evaluation windows to obtain the degree of polarization uniformity (DOPU). By use of a PS-OCT system with an integrated retinal tracker, we analyze optimum conditions for depolarization imaging, data processing, and segmentation of depolarizing tissue in the human retina. The trade-offs between figures of merit like DOPU imaging sensitivity, efficiency, and susceptibility are evaluated in terms of 3-D resolution. The results are used for a new, detailed interpretation of PS-OCT high-resolution images of the human retinal pigment epithelium and Bruch’s membrane.

Paper Details

Date Published: 13 January 2015
PDF: 15 pages
J. Biomed. Opt. 20(1) 016011 doi: 10.1117/1.JBO.20.1.016011
Published in: Journal of Biomedical Optics Volume 20, Issue 1
Show Author Affiliations
Mitsuro Sugita, Medizinische Univ. Wien (Austria)
Canon Inc. (Japan)
Michael Pircher, Medizinische Univ. Wien (Austria)
Stefan Zotter, Medizinische Univ. Wien (Austria)
Bernhard Baumann, Medizinische Univ. Wien (Austria)
Kenichi Saito, Canon Inc. (Japan)
Tomoyuki Makihira, Canon Inc. (Japan)
Nobuhiro Tomatsu, Canon Inc. (Japan)
Makoto Sato, Canon Inc. (Japan)
Christoph K. Hitzenberger, Medizinische Univ. Wien (Austria)

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