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Journal of Biomedical Optics

Photocontrolled nitric oxide release from two nitrosylruthenium isomer complexes and their potential biomedical applications
Author(s): Jiao Liu; Qingqing Duan; Jianru Wang; Zhen Song; Xiaoyan Qiao; Hongfei Wang
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Paper Abstract

Nitric oxide (NO) has key regulatory roles in various biological and medical processes. The control of its local concentration, which is crucial for obtaining the desired effect, can be achieved with exogenous NO donors. Release of NO from metal-nitrosyl complexes upon exposure to light is a strategy that could allow for the site-specific delivery of the reactive species NO to physiological targets. The photodissociation of NO from two nitrosylruthenium(II) isomer complexes {cis- and trans-[Ru(OAc)(2mqn)2NO]} was demonstrated by matrix-assisted laser desorption ionization time-of-flight mass spectrometry spectra, and electron paramagnetic resonance spectra further prove the photoinduced NO release by spin trapping of NO free radicals upon photoirradiation. Real-time NO release was quantitatively measured by electrochemistry with an NO-specific electrode. The quantitative control of NO release from [Ru(OAc)(2mqn)2NO] in aqueous solutions was done by photoirradiation at different wavelengths. Both isomers show photoinduced damage on plasmid DNA, but the trans isomer has higher cytotoxicity and photocytotoxicity activity against the HeLa tumor cell line than that of the cis isomer. Nitrosylruthenium(II) complex, with 8-quinolinol derivatives as ligands, has a great potential as a photoactivated NO donor reagent for biomedical applications.

Paper Details

Date Published: 26 January 2015
PDF: 7 pages
J. Biomed. Opt. 20(1) 015004 doi: 10.1117/1.JBO.20.1.015004
Published in: Journal of Biomedical Optics Volume 20, Issue 1
Show Author Affiliations
Jiao Liu, Shanxi Univ. (China)
Qingqing Duan, Shanxi Univ. (China)
Jianru Wang, Shanxi Univ. (China)
Zhen Song, Shanxi Univ. (China)
Xiaoyan Qiao, Shanxi Univ. (China)
Hongfei Wang, Shanxi Univ. (China)

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