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Journal of Biomedical Optics • Open Access

Temperature-controlled in vivo ocular exposure to 1090-nm radiation suggests that near-infrared radiation cataract is thermally induced
Author(s): Zhaohua Yu; Karl Schulmeister; Nooshin Talebizadeh; Martin Kronschläger; Per Söderberg

Paper Abstract

The damage mechanism for near-infrared radiation (IRR) induced cataract is unclear. Both a photochemical and a thermal mechanism were suggested. The current paper aims to elucidate a photochemical effect based on investigation of irradiance-exposure time reciprocity. Groups of 20 rats were unilaterally exposed to 96-W/cm2 IRR at 1090 nm within the dilated pupil accumulating 57, 103, 198, and 344  kJ/cm2, respectively. Temperature was recorded at the limbus of the exposed eye. Seven days after exposure, the lenses were macroscopically imaged and light scattering was quantitatively measured. The average maximum temperature increases for exposure times of 10, 18, 33, and 60 min were expressed as 7.0±1.1, 6.8±1.1, 7.6±1.3, and 7.4±1.1°C [CI (0.95)] at the limbus of the exposed eye. The difference of light scattering in the lenses between exposed and contralateral not-exposed eyes was 0.00±0.02, 0.01±0.03, −0.01±0.02, and −0.01±0.03 transformed equivalent diazepam concentration (tEDC), respectively, and no apparent morphological changes in the lens were observed. An exposure to 96-W/cm2 1090-nm IRR projected on the cornea within the dilated pupil accumulating radiant exposures up to 344  kJ/cm2 does not induce cataract if the temperature rise at the limbus is <8°C. This is consistent with a thermal damage mechanism for IRR-induced cataract.

Paper Details

Date Published: 20 January 2015
PDF: 4 pages
J. Biomed. Opt. 20(1) 015003 doi: 10.1117/1.JBO.20.1.015003
Published in: Journal of Biomedical Optics Volume 20, Issue 1
Show Author Affiliations
Zhaohua Yu, Uppsala Univ. (Sweden)
Karl Schulmeister, Seibersdorf Labor GmbH (Austria)
Nooshin Talebizadeh, Uppsala Univ. (Sweden)
Martin Kronschläger, Uppsala Univ. (Sweden)
Per Söderberg, Uppsala Univ. (Sweden)


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