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Journal of Biomedical Optics • Open Access

Noninvasive diagnosis and therapeutic effect evaluation of deep vein thrombosis in clinics by near-infrared spectroscopy
Author(s): Ting Li; Yunlong Sun; Xiao Chen; Yue Zhao; Rongrong Ren

Paper Abstract

Deep vein thrombosis (DVT) has become a severe disease with a rising incidence rate. The conventional diagnosis relies on complicated imaging modalities that may also involve invasive contrast agent injection and ionizing procedures (e.g., venography). Noninvasive near-infrared spectroscopy (NIRS) methods have been explored which required the DVT patients to follow some exercise protocols. Here, we attempt to use portable NIRS under patients’ natural state for DVT diagnosis. Nine DVT patients and seven healthy subjects participated in NIRS measurements of concentration of oxy- and deoxy-hemoglobins (Δ[HbO2] and Δ[Hb]) relative to data on a tissue mimicking phantom at six particular sites of calves. It was found that Δ[HbO2] is significantly lower in DVT patients than healthy ones, whereas Δ[Hb] is distinctly higher. Moreover, after thrombolytic therapy, both Δ[HbO2] and Δ[Hb] in DVT calves assume a gradual convergence to the curves of healthy ones. This reveals the potential of NIRS for the noninvasive, continuous, and straightforward monitoring/therapeutic effect evaluation of DVT in clinics with appropriate bedside monitoring capability.

Paper Details

Date Published: 20 January 2015
PDF: 3 pages
J. Biomed. Opt. 20(1) 010502 doi: 10.1117/1.JBO.20.1.010502
Published in: Journal of Biomedical Optics Volume 20, Issue 1
Show Author Affiliations
Ting Li, Univ. of Electronic Science and Technology of China (China)
Yunlong Sun, Univ. of Electronic Science and Technology of China (China)
Xiao Chen, Univ. of Electronic Science and Technology of China (China)
Yue Zhao, Univ. of Electronic Science and Technology of China (China)
Rongrong Ren, Xinhua Hospital (China)

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