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Journal of Biomedical Optics • Open Access

Real-time monitoring of hemodynamic changes in tumor vessels during photoimmunotherapy using optical coherence tomography
Author(s): Chia-Pin Liang; Takahito Nakajima; Rira Watanabe; Kazuhide Sato; Peter L. Choyke; Yu Chen; Hisataka Kobayashi

Paper Abstract

Photoimmunotherapy (PIT) is a cell-specific cancer therapy based on an armed antibody conjugate that induces rapid and highly selective cancer cell necrosis after exposure to near-infrared (NIR) light. The PIT treatment also induces the superenhanced permeability and retention effect, which allows high concentrations of nanoparticles to accumulate in the tumor bed. In our pilot studies, optical coherence tomography (OCT) reveals dramatic hemodynamic changes during PIT. We developed and applied speckle variance analysis, Doppler flow measurement, bulk motion removal, and automatic region of interest selection to quantify vessel diameter and blood velocity within tumors

Paper Details

Date Published: 24 September 2014
PDF: 6 pages
J. Biomed. Opt. 19(9) 098004 doi: 10.1117/1.JBO.19.9.098004
Published in: Journal of Biomedical Optics Volume 19, Issue 9
Show Author Affiliations
Chia-Pin Liang, Univ. of Maryland, College Park (United States)
Takahito Nakajima, National Cancer Institute (United States)
Rira Watanabe, National Cancer Institute (United States)
Kazuhide Sato, National Cancer Institute (United States)
Peter L. Choyke, National Cancer Institute (United States)
Yu Chen, Univ. of Maryland, College Park (United States)
Hisataka Kobayashi, National Cancer Institute (United States)

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