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Journal of Biomedical Optics • Open Access

Spatial mapping of dynamic cerebral autoregulation by multichannel near-infrared spectroscopy in high-grade carotid artery disease
Author(s): Matthias Reinhard; F. Konrad Schumacher; Sebastian Rutsch; Maximilian Oeinck; Jens Timmer; Irina Mader; Björn Schelter; Cornelius Weiller; Christoph P. Kaller

Paper Abstract

The exact spatial distribution of impaired cerebral autoregulation in carotid artery disease is unknown. In this pilot study, we present a new approach of multichannel near-infrared spectroscopy (mcNIRS) for noninvasive spatial mapping of dynamic autoregulation in carotid artery disease. In 15 patients with unilateral severe carotid artery stenosis or occlusion, cortical hemodynamics in the bilateral frontal cortex were assessed from changes in oxyhemoglobin concentration using 52-channel NIRS (spatial resolution ∼2  cm). Dynamic autoregulation was graded by the phase shift between respiratory-induced 0.1 Hz oscillations of blood pressure and oxyhemoglobin. Ten of 15 patients showed regular phase values in the expected (patho) physiological range. Five patients had clearly outlying irregular phase values mostly due to artifacts. In patients with a regular phase pattern, a significant side-to-side difference of dynamic autoregulation was observed for the cortical border zone area between the middle and anterior cerebral artery ([i]p<0.05). In conclusion, dynamic cerebral autoregulation can be spatially assessed from slow hemodynamic oscillations with mcNIRS. In high-grade carotid artery disease, cortical dynamic autoregulation is affected mostly in the vascular border zone. Spatial mapping of dynamic autoregulation may serve as a powerful tool for identifying brain regions at specific risks for hemodynamic infarction.

Paper Details

Date Published: 24 September 2014
PDF: 9 pages
J. Biomed. Opt. 19(9) 097005 doi: 10.1117/1.JBO.19.9.097005
Published in: Journal of Biomedical Optics Volume 19, Issue 9
Show Author Affiliations
Matthias Reinhard, Univ. Medical Ctr. Freiburg (Germany)
F. Konrad Schumacher, Univ. Medical Ctr. Freiburg (Germany)
Sebastian Rutsch, Univ. Medical Ctr. Freiburg (Germany)
Maximilian Oeinck, Univ. Medical Ctr. Freiburg (Germany)
Jens Timmer, Univ. of Freiburg (Germany)
Irina Mader, Univ. Medical Ctr. Freiburg (Germany)
Björn Schelter, Univ. of Freiburg (Germany)
Cornelius Weiller, Univ. Medical Ctr. Freiburg (Germany)
Christoph P. Kaller, Univ. Medical Ctr. Freiburg (Germany)
Univ. of Freiburg (Germany)

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