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Journal of Biomedical Optics • Open Access

Monitoring of tumor radio frequency ablation using derivative spectroscopy
Author(s): Jarich W. Spliethoff; Erik Tanis; Daniel J. Evers; Benno H. Hendriks; Warner Prevoo; Theo J. Ruers

Paper Abstract

Despite the widespread use of radio frequency (RF) ablation, an effective way to assess thermal tissue damage during and after the procedure is still lacking. We present a method for monitoring RF ablation efficacy based on thermally induced methemoglobin as a marker for full tissue ablation. Diffuse reflectance (DR) spectra were measured from human blood samples during gradual heating of the samples from 37 to 60, 70, and 85°C. Additionally, reflectance spectra were recorded real-time during RF ablation of human liver tissue

Paper Details

Date Published: 19 September 2014
PDF: 8 pages
J. Biomed. Opt. 19(9) 097004 doi: 10.1117/1.JBO.19.9.097004
Published in: Journal of Biomedical Optics Volume 19, Issue 9
Show Author Affiliations
Jarich W. Spliethoff, The Netherlands Cancer Institute (Netherlands)
Erik Tanis, The Netherlands Cancer Institute (Netherlands)
Daniel J. Evers, The Netherlands Cancer Institute (Netherlands)
Benno H. Hendriks, Philips Research Nederland B.V. (Netherlands)
Warner Prevoo, The Netherlands Cancer Institute (Netherlands)
Theo J. Ruers, The Netherlands Cancer Institute (Netherlands)
University of Twente (The Netherlands)

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