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Journal of Biomedical Optics

Microcirculatory changes identified by photoacoustic microscopy in patients with complex regional pain syndrome type I after stellate ganglion blocks
Author(s): Yong Zhou; Xiaobin Yi; Wenxin Xing; Song Hu; Konstantin I. Maslov; Lihong V. Wang
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Paper Abstract

Complex regional pain syndrome (CRPS) is a chronic pain syndrome that causes intractable pain, disability, and poor quality of life for patients. The etiology and pathophysiology of CRPS are still poorly understood. Due to a lack of proper diagnostic tools, the prognosis of CRPS is primarily based on clinical observation. The objective of this work is to evaluate a new imaging modality, photoacoustic microscopy (PAM), for assisting diagnoses and monitoring the progress and treatment outcome of CRPS. Blood vasculature and oxygen saturation (sO 2 ) were imaged by PAM from eight adult patients with CRPS-1. Patients’ hands and cuticles were imaged both before and after stellate ganglion block (SGB) for comparison. For all patients, both vascular structure and sO 2 could be assessed by PAM. In addition, more vessels and stronger signals were observed after SGB. The results show that PAM can help diagnose and monitor CRPS.

Paper Details

Date Published: 21 August 2014
PDF: 6 pages
J. Biomed. Opt. 19(8) 086017 doi: 10.1117/1.JBO.19.8.086017
Published in: Journal of Biomedical Optics Volume 19, Issue 8
Show Author Affiliations
Yong Zhou, Washington Univ. in St. Louis (United States)
Xiaobin Yi, Washington Univ. School of Medicine in St. Louis (United States)
Wenxin Xing, Washington Univ. in St. Louis (United States)
Song Hu, Washington Univ. in St. Louis (United States)
Konstantin I. Maslov, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)

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