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Journal of Biomedical Optics • Open Access

Histogram flow mapping with optical coherence tomography for in vivo skin angiography of hereditary hemorrhagic telangiectasia
Author(s): Kyle H. Cheng; Adrian Mariampillai; Kenneth K. Lee; Barry Vuong; Timothy W. Luk; Joel Ramjist; M. Anne Curtis; Henry Jakubovic; Peter Kertes; Michelle Letarte; Marie E. Faughnan; Victor X. Yang

Paper Abstract

Speckle statistics of flowing scatterers have been well documented in the literature. Speckle variance optical coherence tomography exploits the large variance values of intensity changes in time caused mainly by the random backscattering of light resulting from translational activity of red blood cells to map out the microvascular networks. A method to map out the microvasculature malformation of skin based on the time-domain histograms of individual pixels is presented with results obtained from both normal skin and skin containing vascular malformation. Results demonstrated that this method can potentially map out deeper blood vessels and enhance the visualization of microvasculature in low signal regions, while being resistant against motion (e.g., patient tremor or internal reflex movements). The overall results are manifested as more uniform en face projection maps of microvessels. Potential applications include clinical imaging of skin vascular abnormalities and wide-field skin angiography for the study of complex vascular networks.

Paper Details

Date Published: 20 August 2014
PDF: 6 pages
J. Biomed. Opt. 19(8) 086015 doi: 10.1117/1.JBO.19.8.086015
Published in: Journal of Biomedical Optics Volume 19, Issue 8
Show Author Affiliations
Kyle H. Cheng, Univ. of Toronto (Canada)
Ryerson Univ. (Canada)
Adrian Mariampillai, Ryerson Univ. (Canada)
Kenneth K. Lee, Univ. of Toronto (Canada)
Ryerson Univ. (Canada)
Barry Vuong, Ryerson Univ. (Canada)
Timothy W. Luk, Ryerson Univ. (Canada)
Joel Ramjist, Ryerson Univ. (Canada)
M. Anne Curtis, Univ. of Toronto (Canada)
Henry Jakubovic, Univ. of Toronto (Canada)
Peter Kertes, Univ. of Toronto (Canada)
Michelle Letarte, The Hospital for Sick Children (SickKids) (Canada)
Univ. of Toronto (Canada)
Marie E. Faughnan, Univ. of Toronto (Canada)
Victor X. Yang, Ryerson Univ. (Canada)

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