Share Email Print
cover

Paper Abstract

The nEUROPt protocol is one of two new protocols developed within the European project nEUROPt to characterize the performances of time-domain systems for optical imaging of the brain. It was applied in joint measurement campaigns to compare the various instruments and to assess the impact of technical improvements. This protocol addresses the characteristic of optical brain imaging to detect, localize, and quantify absorption changes in the brain. It was implemented with two types of inhomogeneous liquid phantoms based on Intralipid and India ink with well-defined optical properties. First, small black inclusions were used to mimic localized changes of the absorption coefficient. The position of the inclusions was varied in depth and lateral direction to investigate contrast and spatial resolution. Second, two-layered liquid phantoms with variable absorption coefficients were employed to study the quantification of layer-wide changes and, in particular, to determine depth selectivity, i.e., the ratio of sensitivities for deep and superficial absorption changes. We introduce the tests of the nEUROPt protocol and present examples of results obtained with different instruments and methods of data analysis. This protocol could be a useful step toward performance tests for future standards in diffuse optical imaging.

Paper Details

Date Published: 14 August 2014
PDF: 12 pages
J. Biomed. Opt. 19(8) 086012 doi: 10.1117/1.JBO.19.8.086012
Published in: Journal of Biomedical Optics Volume 19, Issue 8
Show Author Affiliations
Heidrun Wabnitz, Physikalisch-Technische Bundesanstalt (Germany)
Alexander Jelzow, Physikalisch-Technische Bundesanstalt (Germany)
Mikhail Mazurenka, Physikalisch-Technische Bundesanstalt (Germany)
Oliver Steinkellner, Physikalisch-Technische Bundesanstalt (Germany)
Rainer Macdonald, Physikalisch-Technische Bundesanstalt (Germany)
Daniel Milej, Institute of Biocybernetics and Biomedical Engineering (Poland)
Norbert Żołek, Institute of Biocybernetics and Biomedical Engineering (Poland)
Michał Kacprzak, Nałęcz Institute of Biocybernetics and Biomedical Engineering (Poland)
Piotr Sawosz, Institute of Biocybernetics and Biomedical Engineering (Poland)
Roman Maniewski, Institute of Biocybernetics and Biomedical Engineering (Poland)
Adam Liebert, Institute of Biocybernetics and Biomedical Engineering (Poland)
Salavat Magazov, Univ. College London (United Kingdom)
Jeremy C. Hebden, Univ. College London (United Kingdom)
Fabrizio Martelli, Univ. degli Studi di Firenze (Italy)
Paola Di Ninni, Univ. degli Studi di Firenze (Italy)
Giovanni Zaccanti, Univ. degli Studi di Firenze (Italy)
Alessandro Torricelli, Politecnico di Milano (Italy)
Davide Contini, Politecnico di Milano (Italy)
Rebecca Re, Politecnico di Milano (Italy)
Lucia M. Zucchelli, Politecnico di Milano (Italy)
Lorenzo Spinelli, Istituto di Fotonica e Nanotecnologie (Italy)
Rinaldo Cubeddu, Politecnico di Milano (Italy)
Istituto di Fotonica e Nanotecnologie (Italy)
Antonio Pifferi, Politecnico di Milano (Italy)
Istituto di Fotonica e Nanotecnologie (Italy)


© SPIE. Terms of Use
Back to Top