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Journal of Biomedical Optics • Open Access

Design and characterization of a handheld multimodal imaging device for the assessment of oral epithelial lesions
Author(s): Laura M. Higgins; Mark C. Pierce

Paper Abstract

A compact handpiece combining high resolution fluorescence (HRF) imaging with optical coherence tomography (OCT) was developed to provide real-time assessment of oral lesions. This multimodal imaging device simultaneously captures coregistered en face images with subcellular detail alongside cross-sectional images of tissue microstructure. The HRF imaging acquires a 712×594  μm2 field-of-view at the sample with a spatial resolution of 3.5  μm. The OCT images were acquired to a depth of 1.5 mm with axial and lateral resolutions of 9.3 and 8.0  μm, respectively. HRF and OCT images are simultaneously displayed at 25 fps. The handheld device was used to image a healthy volunteer, demonstrating the potential for in vivo assessment of the epithelial surface for dysplastic and neoplastic changes at the cellular level, while simultaneously evaluating submucosal involvement. We anticipate potential applications in real-time assessment of oral lesions for improved surveillance and surgical guidance.

Paper Details

Date Published: 7 August 2014
PDF: 7 pages
J. Biomed. Opt. 19(8) 086004 doi: 10.1117/1.JBO.19.8.086004
Published in: Journal of Biomedical Optics Volume 19, Issue 8
Show Author Affiliations
Laura M. Higgins, Rutgers, The State Univ. of New Jersey (United States)
Mark C. Pierce, Rutgers, The State Univ. of New Jersey (United States)

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