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Journal of Biomedical Optics • Open Access

Single-channel prototype terahertz endoscopic system
Author(s): Pallavi Doradla; Karim Alavi; Cecil S. Joseph; Robert H. Giles

Paper Abstract

We demonstrate the design and development of an innovative single-channel terahertz (THz) prototype endoscopic imaging system based on flexible metal-coated THz waveguides and a polarization specific detection technique. The continuous-wave (CW) THz imaging system utilizes a single channel to transmit and collect the reflected intrinsic THz signal from the sample. Since the prototype system relies on a flexible waveguide assembly that is small enough in diameter, it can be readily integrated with a conventional optical endoscope. This study aims to show the feasibility of waveguide enabled THz imaging. We image various objects in transmission and reflection modes. We also image normal and cancerous colonic tissues in reflectance mode using a polarization specific imaging technique. The resulting cross-polarized THz reflectance images showed contrast between normal and cancerous colonic tissues at 584 GHz. The level of contrast observed using endoscopic imaging correlates well with contrast levels observed in <italic<ex vivo</italic< THz reflectance studies of colon cancer. This indicates that the single-channel flexible waveguide-based THz endoscope presented here represents a significant step forward in clinical endoscopic application of THz technology to aid in <italic<in vivo</italic< cancer screening.

Paper Details

Date Published: 11 August 2014
PDF: 3 pages
J. Biomed. Opt. 19(8) 080501 doi: 10.1117/1.JBO.19.8.080501
Published in: Journal of Biomedical Optics Volume 19, Issue 8
Show Author Affiliations
Pallavi Doradla, Univ. of Massachusetts Lowell (United States)
Karim Alavi, Univ. of Massachusetts Medical School (United States)
Cecil S. Joseph, Univ. of Massachusetts Lowell (United States)
Robert H. Giles, Univ. of Massachusetts Lowell (United States)

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