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Journal of Biomedical Optics • Open Access

Label-free immunodetection of the cancer biomarker CA125 using high-Δn liquid crystals
Author(s): Hui-Wen Su; Yun-Han Lee; Mon-Juan Lee; Yi-Chiang Hsu; Wei Lee

Paper Abstract

A label-free and array-based optical liquid-crystal (LC) immunodetection technique for the detection of CA125 antigen, a protein biomarker most frequently used for ovarian cancer detection, was demonstrated with a nematic LC with larger birefringence (Δn) to promote sensitivity in detecting biomolecules. The LC-based immunodetection offers an alternative and sensitive approach for the detection of biomarker proteins, with the potential of replacing conventional immunoassays used in biochemical studies and clinical laboratories.

Paper Details

Date Published: 23 July 2014
PDF: 6 pages
J. Biomed. Opt. 19(7) 077006 doi: 10.1117/1.JBO.19.7.077006
Published in: Journal of Biomedical Optics Volume 19, Issue 7
Show Author Affiliations
Hui-Wen Su, National Chiao Tung Univ. (Taiwan)
Yun-Han Lee, National Chiao Tung Univ. (Taiwan)
Mon-Juan Lee, Chang Jung Christian Univ. (Taiwan)
Yi-Chiang Hsu, Chang Jung Christian Univ. (Taiwan)
Wei Lee, National Chiao Tung Univ. (Taiwan)

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