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Journal of Biomedical Optics • Open Access

Terahertz pulsed spectroscopy of paraffin-embedded brain glioma
Author(s): Kun Meng; Tu-nan Chen; Tao Chen; Li-guo Zhu; Qiao Liu; Zhao Li; Fei Li; Sen-cheng Zhong; Ze-ren Li; Hua Feng; Jian-heng Zhao

Paper Abstract

The refractive indices, absorption coefficients, and complex dielectric constants of paraffin-embedded brain glioma and normal brain tissues have been measured by a terahertz time-domain spectroscopy (THz-TDS) system in the 0.2- to 2.0-THz range. The spectral differences between gliomas and normal brain tissues were obtained. Compared with normal brain tissue, our results indicate that paraffin-embedded brain gliomas have a higher refractive index, absorption coefficient, and dielectric constant. Based on these results, the best THz frequencies for different methods of paraffin-embedded brain glioma imaging, such as intensity imaging, coherent imaging with continuum THz sources, and THz pulsed imaging with short-pulsed THz sources, are analyzed.

Paper Details

Date Published: 7 July 2014
PDF: 6 pages
J. Biomed. Opt. 19(7) 077001 doi: 10.1117/1.JBO.19.7.077001
Published in: Journal of Biomedical Optics Volume 19, Issue 7
Show Author Affiliations
Kun Meng, China Academy of Engineering Physics (China)
Tu-nan Chen, China Academy of Engineering Physics (China)
Third Military Medical Univ. (China)
Tao Chen, China Academy of Engineering Physics (China)
Li-guo Zhu, China Academy of Engineering Physics (China)
Qiao Liu, China Academy of Engineering Physics (China)
Zhao Li, Third Military Medical Univ. (China)
Fei Li, Third Military Medical Univ. (China)
Sen-cheng Zhong, China Academy of Engineering Physics (China)
Ze-ren Li, China Academy of Engineering Physics (China)
Hua Feng, Third Military Medical Univ. (China)
Jian-heng Zhao, China Academy of Engineering Physics (China)


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