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Journal of Biomedical Optics

Interlaced photoacoustic and ultrasound imaging system with real-time coregistration for ovarian tissue characterization
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Paper Abstract

Coregistered ultrasound (US) and photoacoustic imaging are emerging techniques for mapping the echogenic anatomical structure of tissue and its corresponding optical absorption. We report a 128-channel imaging system with real-time coregistration of the two modalities, which provides up to 15 coregistered frames per second limited by the laser pulse repetition rate. In addition, the system integrates a compact transvaginal imaging probe with a custom-designed fiber optic assembly for <italic<in vivo</italic< detection and characterization of human ovarian tissue. We present the coregistered US and photoacoustic imaging system structure, the optimal design of the PC interfacing software, and the reconfigurable field programmable gate array operation and optimization. Phantom experiments of system lateral resolution and axial sensitivity evaluation, examples of the real-time scanning of a tumor-bearing mouse, and <italic<ex vivo</italic< human ovaries studies are demonstrated.

Paper Details

Date Published: 28 July 2014
PDF: 8 pages
J. Biomed. Opt. 19(7) 076020 doi: 10.1117/1.JBO.19.7.076020
Published in: Journal of Biomedical Optics Volume 19, Issue 7
Show Author Affiliations
Umar S. Alqasemi, King Abdulaziz Univ. (Saudi Arabia)
Univ. of Connecticut (United States)
Hai Li, Univ. of Connecticut (United States)
Guangqian Yuan, Univ. of Connecticut (United States)
Patrick D. Kumavor, Univ. of Connecticut (United States)
Saeid Zanganeh, Univ. of Connecticut (United States)
Quing Zhu, Univ. of Connecticut (United States)

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