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Journal of Biomedical Optics

Cost-efficient laser-diode-induced optical-resolution photoacoustic microscopy for two-dimensional/three-dimensional biomedical imaging
Author(s): Lvming Zeng; Guodong Liu; Diwu Yang; Xuanrong Ji
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Paper Abstract

Solid-state laser systems, such as traditional Nd:YAG-based lasers, are commonly used for noninvasive biomedical photoacoustics with nanosecond pulse duration and millijoule pulse energy. However, such lasers are both bulky and expensive for use as a handy tool for clinical applications. As an alternative, a semiconductor light source has the advantages of being compact, inexpensive, and robust. In addition, the main drawback of low peak output power may make it exactly suitable for the imaging modalities, which require relatively low pulse energies, such as acoustic- and optical-resolution photoacoustic microscopy (AR/OR-PAM). We propose a cost-efficient OR-PAM for two-dimensional/three-dimensional (2-D/3-D) biological imaging based on a pulsed near-infrared laser diode. By raster scanning, typical 2-D photoacoustic images were obtained at different scales, and 3-D surface renderings were clearly reconstructed with a marching cubes algorithm. This initial study would promote the production of portable OR-PAM technology for clinical and biomedical applications.

Paper Details

Date Published: 24 July 2014
PDF: 6 pages
J. Biomed. Opt. 19(7) 076017 doi: 10.1117/1.JBO.19.7.076017
Published in: Journal of Biomedical Optics Volume 19, Issue 7
Show Author Affiliations
Lvming Zeng, Jiangxi Science and Technology Normal Univ. (China)
Guodong Liu, Jiangxi Science and Technology Normal Univ. (China)
Diwu Yang, Hunan Univ. of Technology (China)
Xuanrong Ji, Doppler Electronic Technologies Company Ltd. (China)

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