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Journal of Biomedical Optics

Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues
Author(s): E. Du; Honghui He; Nan Zeng; Minghao Sun; Yihong Guo; Jian Wu; Shaoxiong Liu; Hui Ma
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Paper Abstract

Polarization measurements allow one to enhance the imaging contrast of superficial tissues and obtain new polarization sensitive parameters for better descriptions of the micro- and macro- structural and optical properties of complex tissues. Since the majority of cancers originate in the epithelial layer, probing the morphological and pathological changes in the superficial tissues using an expended parameter set with improved contrast will assist in early clinical detection of cancers. We carry out Mueller matrix imaging on different cancerous tissues to look for cancer specific features. Using proper scattering models and Monte Carlo simulations, we examine the relationship between the microstructures of the samples, which are represented by the parameters of the scattering model and the characteristic features of the Mueller matrix. This study gives new clues on the contrast mechanisms of polarization sensitive measurements for different cancers and may provide new diagnostic techniques for clinical applications.

Paper Details

Date Published: 15 July 2014
PDF: 8 pages
J. Biomed. Opt. 19(7) 076013 doi: 10.1117/1.JBO.19.7.076013
Published in: Journal of Biomedical Optics Volume 19, Issue 7
Show Author Affiliations
E. Du, Graduate School at Shenzhen, Tsinghua Univ. (China)
Honghui He, Graduate School at Shenzhen, Tsinghua Univ. (China)
Nan Zeng, Graduate School at Shenzhen, Tsinghua Univ. (China)
Minghao Sun, Graduate School at Shenzhen, Tsinghua Univ. (China)
Yihong Guo, Graduate School at Shenzhen, Tsinghua Univ. (China)
Tsinghua Univ. (China)
Jian Wu, Graduate School at Shenzhen, Tsinghua Univ. (China)
Shaoxiong Liu, Huazhong Univ. of Science and Technology (China)
Hui Ma, Graduate School at Shenzhen, Tsinghua Univ. (China)
Tsinghua Univ. (China)


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