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Journal of Biomedical Optics • Open Access

Phantoms for diffuse optical imaging based on totally absorbing objects, part 2: experimental implementation

Paper Abstract

We present the experimental implementation and validation of a phantom for diffuse optical imaging based on totally absorbing objects for which, in the previous paper [<italic<J. Biomed. Opt.</italic<<bold<18</bold<(6), 066014, (2013)], we have provided the basic theory. Totally absorbing objects have been manufactured as black polyvinyl chloride (PVC) cylinders and the phantom is a water dilution of intralipid-20% as the diffusive medium and India ink as the absorber, filled into a black scattering cell made of PVC. By means of time-domain measurements and of Monte Carlo simulations, we have shown the reliability, the accuracy, and the robustness of such a phantom in mimicking typical absorbing perturbations of diffuse optical imaging. In particular, we show that such a phantom can be used to generate any absorption perturbation by changing the volume and position of the totally absorbing inclusion.

Paper Details

Date Published: 14 July 2014
PDF: 10 pages
J. Biomed. Opt. 19(7) 076011 doi: 10.1117/1.JBO.19.7.076011
Published in: Journal of Biomedical Optics Volume 19, Issue 7
Show Author Affiliations
Fabrizio Martelli, Univ. degli Studi di Firenze (Italy)
Paola Di Ninni, Univ. degli Studi di Firenze (Italy)
Giovanni Zaccanti, Univ. degli Studi di Firenze (Italy)
Davide Contini, Politecnico di Milano (Italy)
Lorenzo Spinelli, Istituto di Fotonica e Nanotecnologie (Italy)
Alessandro Torricelli, Politecnico di Milano (Italy)
Rinaldo Cubeddu, Istituto di Fotonica e Nanotecnologie (Italy)
Politecnico di Milano (Italy)
Heidrun Wabnitz, Physikalisch-Technische Bundesanstalt (Germany)
Mikhail Mazurenka, Physikalisch-Technische Bundesanstalt (Germany)
Rainer Macdonald, Physikalisch-Technische Bundesanstalt (Germany)
Angelo Sassaroli, Tufts Univ. (United States)
Antonio Pifferi, Politecnico di Milano (Italy)
Istituto di Fotonica e Nanotecnologie (Italy)


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