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Journal of Biomedical Optics

X-ray micromodulated luminescence tomography in dual-cone geometry
Author(s): Wenxiang Cong; Zhengwei Pan; Robert J. Filkins; Alok M. Srivastava; A. Nadeem Ishaque; Plamen Stefanov; Ge Wang
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Paper Abstract

We propose a scanning method utilizing dual-cone beams of x-rays to induce luminescence from nanophosphors and reconstruct the three-dimensional distribution of these particles in a biological sample or a small animal. For this purpose, x-rays are focused through a polycapillary lens onto a spot of a few micrometers in size. Such x-ray scanning can be point-wise performed to acquire photon emission data on an object surface. The x-ray-induced luminescence data allow for reliable image reconstruction with high spatial resolution and large imaging depth. We describe several numerical simulation studies to demonstrate the feasibility and merits of the proposed approach.

Paper Details

Date Published: 2 July 2014
PDF: 5 pages
J. Biomed. Opt. 19(7) 076002 doi: 10.1117/1.JBO.19.7.076002
Published in: Journal of Biomedical Optics Volume 19, Issue 7
Show Author Affiliations
Wenxiang Cong, Rensselaer Polytechnic Institute (United States)
Zhengwei Pan, The Univ. of Georgia (United States)
Robert J. Filkins, GE Global Research (United States)
Alok M. Srivastava, GE Global Research (United States)
A. Nadeem Ishaque, GE Global Research (United States)
Plamen Stefanov, Purdue Univ. (United States)
Ge Wang, Rensselaer Polytechnic Institute (United States)

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