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Journal of Biomedical Optics

New eye phantom for ophthalmic surgery
Author(s): Gessica Fogli; Gianni Orsi; Carmelo De Maria; Francesca Montemurro; Michele Palla; Stanislao Rizzo; Giovanni Vozzi
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Paper Abstract

In this work, we designed and realized a new phantom able to mimic the principal mechanical, rheological, and physical cues of the human eye and that can be used as a common benchmark to validate new surgical procedures, innovative vitrectomes, and as a training system for surgeons. This phantom, in particular its synthetic humor vitreous, had the aim of reproducing diffusion properties of the natural eye and can be used as a system to evaluate the pharmacokinetics of drugs and optimization of their dose, limiting animal experiments. The eye phantom was built layer-by-layer starting from the sclera up to the retina, using low cost and easy to process polymers. The validation of the phantom was carried out by mechanical characterization of each layer, by diffusion test with commercial drugs into a purposely developed apparatus, and finally by a team of ophthalmic surgeons. Experiments demonstrated that polycaprolactone, polydimethylsiloxane, and gelatin, properly prepared, are the best materials to mimic the mechanical properties of sclera, choroid, and retina, respectively. A polyvinyl alcohol-gelatin polymeric system is the best for mimicking the viscosity of the human humor vitreous, even if the bevacizumab half-life is lower than in the human eye.

Paper Details

Date Published: 2 June 2014
PDF: 8 pages
J. Biomed. Opt. 19(6) 068001 doi: 10.1117/1.JBO.19.6.068001
Published in: Journal of Biomedical Optics Volume 19, Issue 6
Show Author Affiliations
Gessica Fogli, Univ. di Pisa (Italy)
Gianni Orsi, Univ. di Pisa (Italy)
Carmelo De Maria, Univ. di Pisa (Italy)
Francesca Montemurro, Univ. di Pisa (Italy)
Michele Palla, Azienda Ospedaliero-Univ. Pisana (Italy)
Stanislao Rizzo, Azienda Ospedaliero-Univ. Pisana (Italy)
Giovanni Vozzi, Univ. di Pisa (Italy)


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